Injections of hyaluronic acid (HA) and polylactic acid (PLA) temporarily increased penile girth in men with small penis syndrome (SPS), according to a new Journal of Sexual Medicine study.

The effects lasted for the study’s 24-week duration, and no study participants experienced serious adverse events, researchers said. Many participants reported decreased levels of psychological distress.

Men with small penis syndrome feel anxious about their penis size, even when their penis measurements fall into a normal range. Education and psychotherapy are typical first approaches to treatment, but they are not effective for all patients.

Penile augmentation (PA) is another option. PA involves injecting a soft tissue filler into the penis. Such fillers are commonly used for other body areas like the face, but their use for PA has not been studied as thoroughly.

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